Regulation of Endogenous Glucose Production by Brain Insulin Action

Summary

It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production. Animal studies have shown that the hormone insulin can act on the brain to indirectly lower glucose production by the liver. We aim to test whether this is true in humans by giving insulin intranasally. It has previously been shown that a nasal spray can deliver insulin directly to the brain without affecting circulating insulin concentration.

Timeline

Start

2013-11

Primary completion

2014-07

Completion

2014-07

Drugs

Indications