Investigation Of The Metabolism, And Excretion Of [14c]-PF-05212384 In Healthy Male Volunteers

Phase 1 Completed 6 enrolled Pfizer

NaSingle-groupOpen-labelBasic science

Summary

The purpose of the study is to characterize how PF-05212384 is metabolized in the body following a single intravenous dose of radioactively labeled drug (\[14C\]-PF-05212384).

Timeline

Start: 2014-07
Primary completion: 2014-08
Completion: 2014-08

Publications

Houk BE, Alvey CW, Visswanathan R, Kirkovsky L, Matschke KT, Kimoto E, Ryder T, Obach RS, Durairaj C. Distribution, Metabolism, and Excretion of Gedatolisib in Healthy Male Volunteers After a Single Intravenous Infusion. Clin Pharmacol Drug Dev. 2019 Jan;8(1):22-31. doi: 10.1002/cpdd.615. Epub 2018 Sep 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Gedatolisib	Small molecule	89 mg	Intravenous

Indications

No indication recorded.