drugset / Trial / NCT02143323
A Clinical Study to Explore Biomarkers for Drug-induced Liver Injury (DILI)
Non-randomizedParallel-groupOpen-labelTreatment
Summary
This study has an open-label, one-sequence, multiple drug administration design. The purpose of this study is as follows; * To evaluate the change of liver function according to glutathione s-transferase (GST) genotype after the multiple administration of amoxicillin/clavulanate. * To evaluate the intrinsic metabolite, human leukocyte antigen (HLA) genotype, and microRNA (miRNA) based on liver function change as the candidate biomarker for DILI.
Timeline
- Start
- 2013-12
- Primary completion
- 2014-08
- Completion
- 2014-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | AMOXICILIN | Unknown | — | — |
| Comparator | clavualanate | Unknown | — | — |
Indications
No indication recorded.