Pilot Study of Nicotine Nasal Spray and Varenicline on Smoking in Methadone-Maintained Patients

Phase 4 Terminated 7 enrolled University of Cincinnati

RandomizedCrossoverDouble-blindTreatment

Summary

The objective is to provide a preliminary test of the ability of two pharmacological treatments, the nicotine nasal spray and varenicline, relative to placebos, to reduce smoking during the 4 hours following methadone dosing.

Timeline

Start: 2016-03
Primary completion: 2017-08-25
Completion: 2017-08-25

Publications

Livingstone-Banks J, Fanshawe TR, Thomas KH, Theodoulou A, Hajizadeh A, Hartman L, Lindson N. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2023 May 5;5(5):CD006103. doi: 10.1002/14651858.CD006103.pub8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nicotine	Unknown	1 mg	Intranasal
Subject	Varenicline	Small molecule	1 mg	—

Indications

No indication recorded.