Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma

Summary

A randomized Phase II trial to test whether the addition of intraoperative Photofrin-mediated photodynamic therapy to radical pleurectomy and post-operative chemo.improves OS in the treatment of patients with epithelioid MPM. Subjects assigned to the PDT arm will be given the photosensitizer prior to surgery . All subjects will receive maximal surgical debulking. Subjects in the PDT arm will receive intraoperative treatment using real-time, isotropic light dosimetry.

Timeline

Start

2014-06-02

Primary completion

2026-12-16

Completion

2027-12

Publications

• Sun H, Kim MM, Ong YH, Dimofte A, Singhal S, Busch TM, Cengel KA, Zhu TC. Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates. Photochem Photobiol. 2025 Sep-Oct;101(5):1165-1176. doi: 10.1111/php.14063. Epub 2025 Jan 21.

Drugs

Indications