Microflare Protocol in Poor Responders

NCT02185326 ↗

Phase 4 Completed 145 enrolled Woman's Health University Hospital, Egypt

RandomizedParallel-groupOpen-labelTreatment

Summary

The effect of use of the microflare down regulation protocol on the outcome of the IVF/ICSI cycles in poor responders

Timeline

Start: 2014-07
Primary completion: 2014-12
Completion: 2014-12

Outcome

Met primary endpoint

paper The mean number of metaphase II oocytes was 5.2±1.2 in the GH group and 2.8±1.0 in the microflare only group (P<0.001). PMID 26381201 ↗

paper The mean number of fertilized oocytes was higher in the GH group (4.2±1.1) than in the microflare only group (2.5±0.7; P<0.001). PMID 26381201 ↗

Publications

Bayoumi YA, Dakhly DM, Bassiouny YA, Hashish NM. Addition of growth hormone to the microflare stimulation protocol among women with poor ovarian response. Int J Gynaecol Obstet. 2015 Dec;131(3):305-8. doi: 10.1016/j.ijgo.2015.05.034. Epub 2015 Aug 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Somatropin	Protein / enzyme biologic	2.5 mg	Subcutaneous