drugset / Trial / NCT02202512
Effect of Repeated Doses of BI 1060469 and BI 1021958 on Glomerular Filtration Rate (GFR) in Healthy Volunteers
RandomizedParallel-groupSingle-blindTreatment
Summary
Main objective is to investigate the measured glomerular filtration rate (mGFR) as assessed by iohexol clearance in healthy male normovolemic subjects after oral administration of single and repeated doses of BI 1060469, and BI 1021958. The secondary objective of this trial is to investigate the glomerular filtration rate (GFR) as assessed by 24 hours creatinine clearance in healthy male normovolemic subjects after oral administration of single and repeated doses of BI 1060469, and BI 1021958.
Timeline
- Start
- 2014-09
- Primary completion
- 2014-12
- Completion
- 2014-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | BI 1021958 | Unknown | — | Oral |
| Subject | BI 1060469 | Unknown | — | Oral |
| Comparator | Cimetidine | Small molecule | — | Oral |
| Comparator | Naproxen | Small molecule | — | Oral |
Indications
No indication recorded.