Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial

Phase 4 Terminated 15 enrolled Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal

RandomizedParallel-groupQuadruple-blindSupportive care

Summary

The primary objective of this study is to evaluate the feasibility of a randomized controlled trial comparing levothyroxine to placebo in neurologically deceased donors

Timeline

Start: 2014-07
Primary completion: 2016-12
Completion: 2016-12

Outcome

Outcome not reported

Stopped (Enrollment): “Recruitment was too slow and we cannot anticipate to recruit the target sample size”

Publications

Frenette AJ, Williamson D, Williams V, Lagace AM, Charbonney E, Serri K. A Pilot Randomized Controlled Trial Comparing Levothyroxine to Placebo in Neurologically Deceased Donors. Prog Transplant. 2019 Sep;29(3):261-268. doi: 10.1177/1526924819855083. Epub 2019 Jun 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Levothyroxine	Other / unclassified	10 mg	Intravenous

Indications

No indication recorded.