drugset / Trial / NCT02213575
Study 3: Minocycline Decreases Microglia Activation
Phase 2
Completed
5 enrolled
University of Florida
National Heart, Lung, and Blood Institute (NHLBI) · collab
Non-randomizedSingle-groupOpen-labelTreatment
Summary
This study is a mechanistic study that will enroll 9 subjects who are participating in NCT02133872 (which is designed to evaluate minocycline to test the hypothesis that minocycline treatment would produce antihypertensive effects in drug-resistant neurogenic hypertensive individuals) to test whether the antihypertensive effect of minocycline is associated with a decrease in activated microglia in central nervous system autonomic regions as evidenced by changes in PET and MRI imaging.
Timeline
- Start
- 2016-03-05
- Primary completion
- 2018-11-01
- Completion
- 2018-11-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Minocycline | Small molecule | 50 mg | Oral |
| Subject | Minocycline | Small molecule | 100 mg | Oral |
| Subject | Minocycline | Small molecule | 200 mg | Oral |