Value of Immediate Post-operative Intravesical Epirubicin in Intermediate&High Risk Non Muscle Invasive Bladder Cancer

Summary

The aim of the study is to test the value of immediate post-operative intravesical instillation of epirubicin in patients with intermediate and high risk non muscle invasive bladder cancer (NMIBC).

Timeline

Start

2014-07

Primary completion

2017-04

Completion

2017-05

Outcome

Missed primary endpoint

paper There was no statistically significant difference between the 2 groups regarding recurrence rate (27.1% vs. 26.2%) PMID 30448030 ↗

paper Recurrences and progression-free survival were comparable between the 2 groups (Log-rank P = 0.88 and 0.47, respectively). PMID 30448030 ↗

Publications

• Elsawy AA, El-Assmy AM, Bazeed MA, Ali-El-Dein B. The value of immediate postoperative intravesical epirubicin instillation as an adjunct to standard adjuvant treatment in intermediate and high-risk non-muscle-invasive bladder cancer: A preliminary results of randomized controlled trial. Urol Oncol. 2019 Mar;37(3):179.e9-179.e18. doi: 10.1016/j.urolonc.2018.10.019. Epub 2018 Nov 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Epirubicin	Small molecule	50 mg	Other

Indications