drugset / Trial / NCT02224521

GSK2190915A - Bioavailability Study

NCT02224521

Phase 1 Completed 67 enrolled GlaxoSmithKline
RandomizedCrossoverOpen-labelOther

Summary

GSK2190915 is a high affinity 5-lipoxygenase-activating protein (FLAP) inhibitor that reduces inflammation in cells. This study will evaluate three capsule and two tablet formulations to select the optimal formulation for further development. Safety will be assessed through clinical laboratory testing, 12-lead electrocardiogram (ECG), vital signs and Adverse Event/ Serious Adverse Event (AE/ SAE) recording.

Timeline

Start
2009-04-20
Primary completion
2010-06-08
Completion
2010-06-08

Drugs

EvaluationDrugModalityDoseRoute
Subject FIBOFLAPON Small molecule 20 mg
Subject FIBOFLAPON Small molecule 50 mg
Subject FIBOFLAPON Small molecule 100 mg
Subject FIBOFLAPON Small molecule 200 mg

Indications