The Efficacy of a Combination of Telmisartan/S-Amlodipine Compared With Telmisartan Monotherapy

Phase 4 Completed 217 enrolled Chong Kun Dang Pharmaceutical

RandomizedParallel-groupOpen-labelTreatment

Summary

The Efficacy of a Fixed Dose Combination of Telmisartan/S-Amlodipine on 24-hour Ambulatory BP Control Compared with Telmisartan Monotherapy

Timeline

Start: 2014-06
Primary completion: 2018-03
Completion: 2018-03

Outcome

Met primary endpoint

paper Compared to Telmisartan80, Telmisartan40/S-Amlodipine2.5 showed significantly better reductions in 24-h mean SBP and DBP after 8 weeks. PMID 35227313 ↗

Publications

Kim BJ, Cho KI, Kwon HM, Choi SM, Yoon CH, Lim SW, Joo SJ, Lee NH, Lim SY, Lim SH, Kim HS. Effect of a fixed-dose combination of Telmisartan/S-amlodipine on circadian blood pressure compared with Telmisartan monotherapy: TENUVA-BP study. Clin Hypertens. 2022 Mar 1;28(1):7. doi: 10.1186/s40885-021-00184-0.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	S-amlodipine	Unknown	2.5 mg	Oral
Comparator	Telmisartan	Other / unclassified	40 mg	Oral
Comparator	Telmisartan	Other / unclassified	80 mg	Oral