drugset / Trial / NCT02240459
A Study of Fesoterodine and Oxybutynin on Cognitive Function in Mild Cognitive Impairment
RandomizedCrossoverQuadruple-blindOther
Summary
The purpose of this study is to assess the effects of fesoterodine at 4mg and 8mg doses versus a placebo and oxybutynin 5mg bid versus placebo on cognitive abilities in older people with overactive bladder and mild cognitive impairment.
Timeline
- Start
- 2016-08
- Primary completion
- 2020-01-31
- Completion
- 2020-01-31
Publications
- Background Wagg A, Dale M, Tretter R, Stow B, Compion G. Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study. Eur Urol. 2013 Jul;64(1):74-81. doi: 10.1016/j.eururo.2013.01.002. Epub 2013 Jan 11.
- Background Wesnes KA, Edgar C, Tretter RN, Bolodeoku J. Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg. Expert Opin Drug Saf. 2009 Nov;8(6):615-26. doi: 10.1517/14740330903260790.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Fesoterodine | Other / unclassified | 4 mg | Oral |
| Subject | Fesoterodine | Other / unclassified | 8 mg | Oral |
| Subject | Oxybutynin | Small molecule | 5 mg | — |