Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers

Phase 1 Completed 8 enrolled Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd Peking University Cancer Hospital & Institute · collab

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study: Determining the Maximum Tolerated Dose (MTD), Dose-Limiting Toxicity (DLT), pharmacokinetics characteristic, and dosage regimen of phase II/III of Chlorogenic acid for injection in the advanced malignant tumor subjects;

Timeline

Start: 2014-09
Primary completion: 2016-10
Completion: 2016-10

Publications

Zhu H, Chen J, Dong X, Qin X, Li Z. Influence of dihydrocaffeic acid and quinic acid on lung metabolism and function: Implications for dietary interventions. Biochem Biophys Res Commun. 2025 Sep 1;777:152274. doi: 10.1016/j.bbrc.2025.152274. Epub 2025 Jun 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Chlorogenic acid	Small molecule	—	—

Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers

Summary

Timeline

Publications

Drugs

Indications