Hypnosis Before the Induction of Anesthesia

Summary

Hypnosis may reduce patient anxiety. The main goal of this study is to determine in what extent, hypnosis decreases propofol requirement to induce induction of general anesthesia. Two particular aspects of this study are * the inclusion of women undergoing one day gynecological surgical procedures * the use of a closed-loop system which delivers propofol according to bispectral index to provide induction of anesthesia.

Timeline

Start

2014-04

Primary completion

2015-12

Completion

2015-12

Outcome

Missed primary endpoint

paper There was no evidence of a difference in the mean required propofol dose for anaesthetic induction PMID 29210845 ↗

paper failed to detect a difference in the required dose of propofol. PMID 29210845 ↗

Publications

• Background Liu N, Chazot T, Genty A, Landais A, Restoux A, McGee K, Laloe PA, Trillat B, Barvais L, Fischler M. Titration of propofol for anesthetic induction and maintenance guided by the bispectral index: closed-loop versus manual control: a prospective, randomized, multicenter study. Anesthesiology. 2006 Apr;104(4):686-95. doi: 10.1097/00000542-200604000-00012.
• Bataille A, Guirimand A, Szekely B, Michel-Cherqui M, Dumans V, Liu N, Chazot T, Fischler M, Le Guen M. Does a hypnosis session reduce the required propofol dose during closed-loop anaesthesia induction?: A randomised controlled trial. Eur J Anaesthesiol. 2018 Sep;35(9):675-681. doi: 10.1097/EJA.0000000000000751.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	—	—

Indications

No indication recorded.