Influence of Once-daily Versus Twice-daily Immunosuppressant on Renal Transplant

Phase 4 Unknown 90 enrolled National Taiwan University Hospital Astellas Pharma Taiwan, Inc. · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

The main objective of this study was to compare the drug compliance in patients after renal transplantation under once or twice-daily tacrolimus-based immunosuppressive regimen. The rationale for this study is to access the influence of once-daily prolonged-release tacrolimus versus standard twice-daily tacrolimus on drug compliance in renal transplantation recipients base on the assumption that once-daily dosing regimen may help to improve drug compliance.

Timeline

Start: 2014-05-09
Primary completion: 2020-03-31
Completion: 2020-03-31

Publications

Mellon L, Doyle F, Hickey A, Ward KD, de Freitas DG, McCormick PA, O'Connell O, Conlon P. Interventions for increasing immunosuppressant medication adherence in solid organ transplant recipients. Cochrane Database Syst Rev. 2022 Sep 12;9(9):CD012854. doi: 10.1002/14651858.CD012854.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Tacrolimus	Small molecule	—	—

Indications

No indication recorded.