Effect of Anti-Inflammatory Agents on Biological Responses to Endotoxin Inhalation in Healthy Subjects

Phase 0 Completed 51 enrolled Brugmann University Hospital

RandomizedParallel-groupOpen-labelBasic science

Summary

The main objective of this study is to characterize the biological responses elicited by endotoxin inhalation applied to healthy subjects, and to assess the effect of standard anti-inflammatory agents (i.e. adalimumab and methylprednisolone) on these biological responses.

Timeline

Start: 2008-11
Primary completion: 2009-04
Completion: 2009-07

Publications

Michel O, Dinh PH, Doyen V, Corazza F. Anti-TNF inhibits the airways neutrophilic inflammation induced by inhaled endotoxin in human. BMC Pharmacol Toxicol. 2014 Nov 3;15:60. doi: 10.1186/2050-6511-15-60.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Adalimumab	Monoclonal antibody	40 mg	Subcutaneous
Comparator	Methylprednisolone	Other / unclassified	20 mg	Oral

Indications

No indication recorded.