Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

Summary

To determine, in children hospitalized with pneumonia, if an extended duration of oral antibiotics (10 days) will be superior to a shorter duration (3 days) of antibiotics in improving clinical outcomes. Secondary Aims: 1. Describe the prevalence of respiratory viruses and bacteria at presentation. 2. Investigate the depression, anxiety and stress scores (DASS21) and quality of life scored (QOL) by parents of the children during admission, pre-discharge and post discharge and at follow-ups.

Timeline

Start

2014-11

Primary completion

2017-11

Completion

2018-10

Publications

• Results Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 2008 May;86(5):408-16. doi: 10.2471/blt.07.048769.
• Results Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, O'Brien KL, Campbell H, Black RE. Global burden of childhood pneumonia and diarrhoea. Lancet. 2013 Apr 20;381(9875):1405-1416. doi: 10.1016/S0140-6736(13)60222-6. Epub 2013 Apr 12.
• Results Chang AB, Byrnes CA, Everard ML. Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis. Paediatr Respir Rev. 2011 Jun;12(2):97-103. doi: 10.1016/j.prrv.2010.10.008. Epub 2010 Dec 4.
• Results Trenholme AA, Byrnes CA, McBride C, Lennon DR, Chan-Mow F, Vogel AM, Stewart JM, Percival T. Respiratory health outcomes 1 year after admission with severe lower respiratory tract infection. Pediatr Pulmonol. 2013 Aug;48(8):772-9. doi: 10.1002/ppul.22661. Epub 2012 Sep 19.
• Results Gilani Z, Kwong YD, Levine OS, Deloria-Knoll M, Scott JA, O'Brien KL, Feikin DR. A literature review and survey of childhood pneumonia etiology studies: 2000-2010. Clin Infect Dis. 2012 Apr;54 Suppl 2(Suppl 2):S102-8. doi: 10.1093/cid/cir1053.
• Results Yasin RM, Zin NM, Hussin A, Nawi SH, Hanapiah SM, Wahab ZA, Raj G, Shafie N, Peng NP, Chu KK, Aziz MN, Maning N, Mohamad JS, Benjamin A, Salleh MA, Zahari SS, Francis A, Ahmad N, Karunakaran R. Current trend of pneumococcal serotypes distribution and antibiotic susceptibility pattern in Malaysian hospitals. Vaccine. 2011 Aug 5;29(34):5688-93. doi: 10.1016/j.vaccine.2011.06.004. Epub 2011 Jun 30.
• Results Chan PW, Goh AY, Chua KB, Kharullah NS, Hooi PS. Viral aetiology of lower respiratory tract infection in young Malaysian children. J Paediatr Child Health. 1999 Jun;35(3):287-90. doi: 10.1046/j.1440-1754.1999.00359.x.
• Results Kulpeng W, Sornsrivichai V, Chongsuvivatwong V, Rattanavipapong W, Leelahavarong P, Cairns J, Lubell Y, Teerawattananon Y. Variation of health-related quality of life assessed by caregivers and patients affected by severe childhood infections. BMC Pediatr. 2013 Aug 13;13:122. doi: 10.1186/1471-2431-13-122.
• Results Shoham Y, Dagan R, Givon-Lavi N, Liss Z, Shagan T, Zamir O, Greenberg D. Community-acquired pneumonia in children: quantifying the burden on patients and their families including decrease in quality of life. Pediatrics. 2005 May;115(5):1213-9. doi: 10.1542/peds.2004-1285.
• Results Edmond K, Scott S, Korczak V, Ward C, Sanderson C, Theodoratou E, Clark A, Griffiths U, Rudan I, Campbell H. Long term sequelae from childhood pneumonia; systematic review and meta-analysis. PLoS One. 2012;7(2):e31239. doi: 10.1371/journal.pone.0031239. Epub 2012 Feb 22.
• Results Jimenez Ortega AI, Lopez-Neyra A, Sanz Santiago V, Alvarez-Coca J, Villa Asensi JR. [Pulmonary function in children following community-acquired pneumonia contracted at pre-school age]. An Pediatr (Barc). 2011 Nov;75(5):314-9. doi: 10.1016/j.anpedi.2011.05.002. Epub 2011 Jul 31. Spanish.

Drugs

Indications