drugset / Trial / NCT02271282
Estradiol-Receptor Blockade in Older Men and Women
RandomizedCrossoverTriple-blindBasic science
Summary
Repletion of testosterone (Te) in older men drives GH secretion after its aromatization to estradiol (E2), which acts via the estrogen receptor (ER). Conversely, we postulate that estrogen deprivation in postmenopausal women attenuates growth hormone (GH) secretion and insulin-like growth factor-1 (IGF-I) production, thus favoring development of metabolic syndrome in men treated with toremifene, a new estrogen antagonist used adjunctively in prostatic cancer
Timeline
- Start
- 2014-12
- Primary completion
- 2016-05
- Completion
- 2016-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Toremifene | Small molecule | — | Oral |
| Background | Ghrelin | Peptide | 0.3 ug/kg | Intravenous |
| Background | Growth Hormone Releasing Hormone | Unknown | 0.3 ug/kg | Intravenous |
Indications
No indication recorded.