Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases

Summary

This is a randomized pilot study to investigate the ability of a phosphodiesterase-V inhibitor (vardenafil) to increase the concentration of systemically delivered chemotherapy, carboplatin, in patients with recurrent malignant gliomas or metastatic brain cancer. This study will also determine the toxicity and tolerability of a phosphodiesterase-V inhibitor (vardenafil) in combination with intravenous carboplatin for patients with recurrent malignant gliomas or metastatic brain cancer.

Timeline

Start

2012-03-27

Primary completion

2013-10-13

Completion

2016-02-11

Drugs

Indications