Study of the Effect of Dosing on Clozapine Levels

Summary

The objectives of this 15-day study are: 1. To compare steady-state trough plasma concentrations of clozapine and its metabolite norclozapine when given once daily and twice daily (at the same total daily dose) 2. To determine if frequency of clozapine administration has an effect on: 1. Symptoms of schizophrenia 2. Adverse effects of clozapine 3. Fasting blood glucose, lipids, creatinine, and urea 4. Weight and waist circumference

Timeline

Start

2015-01

Primary completion

2017-12

Completion

2017-12

Drugs

Indications