drugset / Trial / NCT02299635

A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations

NCT02299635

Phase 2 Terminated 19 enrolled Pfizer
Open-labelTreatment

Summary

This study is designed to evaluate the preliminary anti-tumor activity and tolerability of PF-03084014 when administered as a single agent in the treatment of patients with advanced triple receptor-negative breast cancer (mTNBC) harboring genomic alterations in Notch receptors (NA+), and in a smaller subset of mTNBC patients whose tumor tests negative for genomic alterations in Notch receptors (NA-)

Timeline

Start
2015-02-03
Primary completion
2016-01-14
Completion
2016-01-14

Drugs

EvaluationDrugModalityDoseRoute
Subject Nirogacestat Small molecule 150 mg Oral