Propofol Pharmacokinetics in Children After Single Bolus Dose

Completed 12 enrolled Post Graduate Institute of Medical Education and Research, Chandigarh

NaSingle-groupOpen-labelHealth-services research

Summary

The principle objective of this study is to evaluate pharmacokinetics of propofol after single iv bolus dose in 12 Indian children and to develop a simple pharmacokinetic model of propofol.

Timeline

Start: 2014-01
Primary completion: 2014-12
Completion: 2015-01

Publications

Background Kataria BK, Ved SA, Nicodemus HF, Hoy GR, Lea D, Dubois MY, Mandema JW, Shafer SL. The pharmacokinetics of propofol in children using three different data analysis approaches. Anesthesiology. 1994 Jan;80(1):104-22. doi: 10.1097/00000542-199401000-00018.
Background Pavan I, Buglione E, Massiccio M, Gregoretti C, Burbi L, Berardino M. Monitoring propofol serum levels by rapid and sensitive reversed-phase high-performance liquid chromatography during prolonged sedation in ICU patients. J Chromatogr Sci. 1992 May;30(5):164-6. doi: 10.1093/chromsci/30.5.164.
Background Marsh B, White M, Morton N, Kenny GN. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth. 1991 Jul;67(1):41-8. doi: 10.1093/bja/67.1.41.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	2.5 mg/kg	Intravenous

Indications

No indication recorded.