Gabapentin for Headache in Aneurysmal Subarachnoid Hemorrhage

Phase 4 Completed 16 enrolled Mayo Clinic

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to see how much gabapentin will reduce headaches associated with subarachnoid hemorrhage (SAH) and to reduce the amount of narcotic pain medication prescribed.

Timeline

Start: 2014-12
Primary completion: 2017-09-01
Completion: 2017-09-01

Outcome

Missed primary endpoint

registry analysis (superiority test); Gabapentin vs Control; p = 0.7; t-test, 2 sided NCT02330094 ↗

registry analysis (superiority test); Gabapentin vs Control; p = 0.79; ANOVA NCT02330094 ↗

Publications

Dhakal LP, Turnbull MT, Jackson DA, Edwards E, Hodge DO, Thottempudi N, Kamireddi P, Akinduro OO, Miller DA, Meschia JF, Freeman WD. Safety, Tolerability, and Efficacy of Pain Reduction by Gabapentin for Acute Headache and Meningismus After Aneurysmal Subarachnoid Hemorrhage: A Pilot Study. Front Neurol. 2020 Jul 28;11:744. doi: 10.3389/fneur.2020.00744. eCollection 2020.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Gabapentin	Unknown	—	Oral