Better Than Study: Targeting Heavy Alcohol Use With Naltrexone Among Men Who Have Sex With Men (MSM)

Summary

This is a double-blind, placebo-controlled trial of 120 binge-drinking MSM to 12 weeks of naltrexone 50mg, to be taken in anticipation of heavy drinking. Ethnically and racially diverse participants will be recruited using Respondent Driven Sampling as well as active field recruitment. MSM will be seen weekly for alcohol-metabolite urine testing, study drug dispensing, and brief counseling for alcohol use. Safety assessments and behavioral surveys will be completed monthly.

Timeline

Start

2015-04

Primary completion

2021-01

Completion

2021-01

Publications

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• Background Coffin PO, Santos GM, Das M, Santos DM, Huffaker S, Matheson T, Gasper J, Vittinghoff E, Colfax GN. Aripiprazole for the treatment of methamphetamine dependence: a randomized, double-blind, placebo-controlled trial. Addiction. 2013 Apr;108(4):751-61. doi: 10.1111/add.12073. Epub 2013 Jan 3.
• Background Coffin PO, Santos GM, Colfax G, Das M, Matheson T, DeMicco E, Dilley J, Vittinghoff E, Raiford JL, Carry M, Herbst JH. Adapted personalized cognitive counseling for episodic substance-using men who have sex with men: a randomized controlled trial. AIDS Behav. 2014 Jul;18(7):1390-400. doi: 10.1007/s10461-014-0712-4.
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• Background Colfax G, Santos GM, Chu P, Vittinghoff E, Pluddemann A, Kumar S, Hart C. Amphetamine-group substances and HIV. Lancet. 2010 Aug 7;376(9739):458-74. doi: 10.1016/S0140-6736(10)60753-2.
• Background Santos GM, Das M, Santos D, Chu P, Vittinghoff E, G. C. Adherence in pharmacotherapy trials among methamphetamine-dependent men who have sex with men (MSM). . North American Congress of Epidemiology. Abstract# 00003039 June, 2011 2011; Montreal, QC
• Background Santos GM, Das M, Matheson T, Vittinghoff E, Dilley J, Colfax G. High-risk sexual behaviors associated with increasing combinations of polysubstances among substance-using men who have sex with men (SUMSM). Abstract# A-452-0270-13751. XIX International AIDS Conference (AIDS 2012). ; July, 2012, 2012; Washington, D.C.
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• Background Santos GM, Beck J, Wilson PA, Hebert P, Makofane K, Pyun T, Do T, Arreola S, Ayala G. Homophobia as a barrier to HIV prevention service access for young men who have sex with men. J Acquir Immune Defic Syndr. 2013 Aug 15;63(5):e167-70. doi: 10.1097/QAI.0b013e318294de80. No abstract available.
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• Background Ruan S, Yang H, Zhu Y, Ma Y, Li J, Zhao J, McFarland W, Raymond HF. HIV prevalence and correlates of unprotected anal intercourse among men who have sex with men, Jinan, China. AIDS Behav. 2008 May;12(3):469-75. doi: 10.1007/s10461-008-9361-9. Epub 2008 Feb 8.
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