Pharmacokinetic of Tacrolimus in Paediatric Liver Transplant Patients

Summary

Tacrolimus is the cornerstone immunosuppressant in children with liver transplantation, its use is complicated by its narrow therapeutic index and variable pharmacokinetics. This study is designed to assess the posology of tacrolimus in post-transplantation in the month after liver transplantation to obtain a therapeutic target between 10-15 ng/mL and the impact of biological and genetic factors on the pharmacokinetic parameters in paediatric liver transplant recipients.

Timeline

Start

2013-12

Primary completion

2020-12

Completion

2020-12

Drugs

Indications