drugset / Trial / NCT02347111
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation
RandomizedCrossoverOpen-labelTreatment
Summary
In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will test the hypothesis that a common AF genetic risk allele modulates response to different AADs.
Timeline
- Start
- 2020-12-31
- Primary completion
- 2026-06-30
- Completion
- 2026-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | flecainide | Small molecule | 150 mg | — |
| Subject | sotalol | Small molecule | 120 mg | Oral |