drugset / Trial / NCT02347111

Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

NCT02347111

Phase 4 Recruiting 162 enrolled University of Illinois at Chicago Medtronic · collab
RandomizedCrossoverOpen-labelTreatment

Summary

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will test the hypothesis that a common AF genetic risk allele modulates response to different AADs.

Timeline

Start
2020-12-31
Primary completion
2026-06-30
Completion
2026-06-30

Drugs

EvaluationDrugModalityDoseRoute
Subject flecainide Small molecule 150 mg
Subject sotalol Small molecule 120 mg Oral

Indications