Inducing Systemic Immunity and Regressions in Metastatic Melanoma

Summary

In patients with multiple metastatic nodules of melanoma, the investigators evaluated whether autologous cytokines injected into cutaneous metastases would induce a systemic immune response as evidenced by the accumulation of dense lymphocytic infiltrates in metastases that had never been injected. Such immune responses were observed, and often the never-injected metastasis regressed completely. 20% of patients remained free of disease for greater than 5 years.

Timeline

Start

1978-07

Primary completion

2002-05

Completion

2002-05

Drugs

Indications