Pretreatments of the Skin Prior to PDT

Phase 1 Completed 12 enrolled Bispebjerg Hospital

NaSingle-groupOpen-labelTreatment

Summary

The study investigates the potential of a range of different physical pretreatments to enhance methyl aminolevulinate (MAL)-induced protoporphyrin IX (PpIX) in the skin prior to photodynamic therapy (PDT).

Timeline

Start: 2014-12
Primary completion: 2014-12
Completion: 2014-12

Publications

Bay C, Lerche CM, Ferrick B, Philipsen PA, Togsverd-Bo K, Haedersdal M. Comparison of Physical Pretreatment Regimens to Enhance Protoporphyrin IX Uptake in Photodynamic Therapy: A Randomized Clinical Trial. JAMA Dermatol. 2017 Apr 1;153(4):270-278. doi: 10.1001/jamadermatol.2016.5268.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	methyl aminolevulinate	Small molecule	0.125 ml	Topical

Indications

No indication recorded.