Lowering Blood Pressure in Primary Care in Vienna

Phase 4 Completed 229 enrolled Wilhelminenspital Vienna Association for the Promotion of Research in Atherosclerosis, Thrombosis and Vascular Biology · collab Ludwig Boltzmann Institute for Cardiovascular Research · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The aim of this prospective, randomised, open-label, multicentre clinical trial is to enhance blood pressure control in primary care by introducing a standardised and simplified titration regime with single pill combinations (SPC), comprising an angiotensin receptor blocker, calcium channel blocker and hydrochlorothiazide.

Timeline

Start: 2015-03
Primary completion: 2017-05-30
Completion: 2017-05-30

Outcome

Met primary endpoint

paper interventional vs. standard care achieved the office BP target (67% ± 26% vs. 39% ± 29%, respectively, mean difference -27.9%, 95% confidence interval CI -54.0%; -1.7%, p = 0.038). PMID 30112584 ↗

Publications

Rohla M, Tscharre M, Huber K, Weiss TW. Lowering blood pressure in primary care in Vienna (LOW-BP-VIENNA) : A cluster-randomized trial. Wien Klin Wochenschr. 2018 Dec;130(23-24):698-706. doi: 10.1007/s00508-018-1374-4. Epub 2018 Aug 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Amlodipine	Other / unclassified	—	—
Subject	Hydrochlorothiazide	Unknown	—	—
Subject	Olmesartan medoxomil	Unknown	—	—