drugset / Trial / NCT02389374
A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh
Phase 4
Completed
181 enrolled
Menzies School of Health Research
International Centre for Diarrhoeal Disease Research, Bangladesh · collab
Non-randomizedParallel-groupOpen-labelTreatment
Summary
This is a study assessing safety and efficacy of current national guidelines for the treatment of uncomplicated malaria in Bangladesh as well as to assess the G6PD status among the enrolled patients.
Timeline
- Start
- 2014-08
- Primary completion
- 2015-03
- Completion
- 2015-03
Publications
- Alam MS, Ley B, Nima MK, Johora FT, Hossain ME, Thriemer K, Auburn S, Marfurt J, Price RN, Khan WA. Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh. Malar J. 2017 Aug 15;16(1):335. doi: 10.1186/s12936-017-1995-5.
- Ley B, Alam MS, Thriemer K, Hossain MS, Kibria MG, Auburn S, Poirot E, Price RN, Khan WA. G6PD Deficiency and Antimalarial Efficacy for Uncomplicated Malaria in Bangladesh: A Prospective Observational Study. PLoS One. 2016 Apr 29;11(4):e0154015. doi: 10.1371/journal.pone.0154015. eCollection 2016.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Artemether-lumefantrine | Unknown | — | — |
| Subject | Chloroquine | Small molecule | — | — |
| Subject | Primaquine | Small molecule | 0.75 mg/kg | — |
| Subject | Primaquine | Small molecule | 3.5 mg/kg | — |