drugset / Trial / NCT02389829
Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Opioids are commonly used to treat migraine in North American Emergency Departments. We are comparing efficacy and adverse events of hydromorphone, an opioid, to that of prochlorperazine, a dopamine antagonist with known efficacy in migraine. Prochlorperazine will be combined with diphenhydramine to prevent adverse events.
Timeline
- Start
- 2015-03
- Primary completion
- 2016-06
- Completion
- 2016-10
Publications
- Cohen F, Friedman BW. A randomized study of IV prochlorperazine plus diphenhydramine versus IV hydromorphone for migraine-associated symptoms: A post hoc analysis. Headache. 2021 Sep;61(8):1227-1233. doi: 10.1111/head.14185. Epub 2021 Aug 7.
- Friedman BW, Irizarry E, Solorzano C, Latev A, Rosa K, Zias E, Vinson DR, Bijur PE, Gallagher EJ. Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine. Neurology. 2017 Nov 14;89(20):2075-2082. doi: 10.1212/WNL.0000000000004642. Epub 2017 Oct 18.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Hydromorphone | Other / unclassified | 1 mg | Intravenous |
| Comparator | Prochlorperazine | Small molecule | 10 mg | Intravenous |
| Comparator | Diphenhydramine | Unknown | 25 mg | Intravenous |