Elucidating the Influence of Lactulose Intake on the Gut Microbiota Composition

Completed 32 enrolled University of Zurich Swiss Federal Institute of Technology in Zurich (ETHZ) · collab

RandomizedParallel-groupQuadruple-blindBasic science

Summary

This study will test the influence of lactulose of the human gut microbiota. Healthy volunteers will ingest 50g of lactulose and donate stool samples 1 day before as well as 1-2 days and 14 days after the test. Using sequencing and metabolomics techniques the investigators will identify changes in microbiota composition upon lactulose exposure.

Timeline

Start: 2015-02
Primary completion: 2015-10-01
Completion: 2015-10-01

Publications

Wotzka SY, Kreuzer M, Maier L, Zund M, Schlumberger M, Nguyen B, Fox M, Pohl D, Heinrich H, Rogler G, Biedermann L, Scharl M, Sunagawa S, Hardt WD, Misselwitz B. Microbiota stability in healthy individuals after single-dose lactulose challenge-A randomized controlled study. PLoS One. 2018 Oct 25;13(10):e0206214. doi: 10.1371/journal.pone.0206214. eCollection 2018.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lactulose	Other / unclassified	50 g	—

Indications

No indication recorded.