Gonadotropin-releasing Hormone (GnRH) Downregulation Versus Oral Anticonception Prior to ART in Postoperative Endometriosis Patients

Summary

Does prolonged GnRH downregulation prior to ART improve the clinical pregnancy rate in postoperative endometriosis patients? (A single centre randomised controlled trial)

Timeline

Start

2013-06

Primary completion

2017-12

Completion

2018-01-26

Outcome

Missed primary endpoint

paper The primary outcome studied-CPHB after the initiated ART treatment-did not differ PMID 34370858 ↗

paper and was 25% (5/20) in the control group, and 20% (4/20) in the ultra-long group (P > 0.999; PMID 34370858 ↗

Publications

• Tomassetti C, Beukeleirs T, Conforti A, Debrock S, Peeraer K, Meuleman C, D'Hooghe T. The ultra-long study: a randomized controlled trial evaluating long-term GnRH downregulation prior to ART in women with endometriosis. Hum Reprod. 2021 Sep 18;36(10):2676-2686. doi: 10.1093/humrep/deab163.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dienogest	Small molecule	—	Oral
Subject	Triptorelin	Other / unclassified	—	—
Comparator	ethinyl estradiol	Small molecule	—	Oral

Indications