Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy

Summary

Clopidogrel has been shown to slow down tumor progression in orthoptic pancreatic murine tumor. In a pilot study, the rate of microparticles was correlated with response rate of pancreatic adenocarcinoma. The aim of the study is; * to compare the phenotypes of coagulation, the tumor progression and metastasis formation with and without clopidogrel treatment in association with chemotherapy in advanced pancreatic cancer patients * to correlate the decrease of microparticles levels after one month of chemotherapy with tumor response (ancillary study)

Timeline

Start

2016-01-11

Primary completion

2017-12-04

Completion

2018-03-27

Drugs

Indications