Intestinal and Humoral Immunity of Sequential Polio Vaccination Schedules

Phase 4 Completed 456 enrolled Centers for Disease Control and Prevention International Centre for Diarrhoeal Disease Research, Bangladesh · collab

RandomizedParallel-groupOpen-labelPrevention

Summary

This is a phase IV open-label randomized clinical trial that will compare intestinal and humoral immunity in infants receiving inactivated poliovirus vaccine (IPV) and two or three doses of bivalent oral poliovirus vaccine (bOPV).

Timeline

Start: 2015-04
Primary completion: 2015-12
Completion: 2015-12

Publications

Snider CJ, Zaman K, Estivariz CF, Aziz AB, Yunus M, Haque W, Hendley WS, Weldon WC, Oberste MS, Pallansch MA, Wassilak SGF, Anand A. Assessing the mucosal intestinal and systemic humoral immunity of sequential schedules of inactivated poliovirus vaccine and bivalent oral poliovirus vaccine for essential immunization in Bangladesh: An open-label, randomized controlled trial. Vaccine. 2024 Sep 17;42(22):126216. doi: 10.1016/j.vaccine.2024.126216. Epub 2024 Aug 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	bivalent oral poliovirus vaccine	Vaccine	—	Oral
Comparator	inactivated poliovirus vaccine	Vaccine	—	—

Intestinal and Humoral Immunity of Sequential Polio Vaccination Schedules

Summary

Timeline

Publications

Drugs

Indications