drugset / Trial / NCT02418533
Mono-menotropins Versus rFSH Protocol on Embryo Quality
RandomizedParallel-groupOpen-labelTreatment
Summary
This study is for couples pursuing in vitro fertilization (IVF) with preimplantation genetic screening (PGS) of embryos to achieve pregnancy. The objective of this clinical trial is to study the effect of mono-menotropins for COS versus recombinant follicle stimulating hormone (rFSH) on cleavage-stage and blastocyst embryo quality after IVF. Embryo quality parameters include conventional embryo grade, early embryo viability assessment (Eeva) time-lapse parameters, and chromosomal aneuploidy rates after PGS. This pilot study is expected to significantly contribute to optimization of treatment regimens and stimulation protocols to optimize embryo quality.
Timeline
- Start
- 2015-03
- Primary completion
- 2017-04
- Completion
- 2017-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gonal-f | Protein / enzyme biologic | 300 iu | Subcutaneous |
| Subject | Gonal-f | Protein / enzyme biologic | 375 iu | Subcutaneous |
| Subject | Gonal-f | Protein / enzyme biologic | 450 iu | Subcutaneous |
| Subject | Menopur | Protein / enzyme biologic | 300 iu | Subcutaneous |
| Subject | Menopur | Protein / enzyme biologic | 375 iu | Subcutaneous |
| Subject | Menopur | Protein / enzyme biologic | 450 iu | Subcutaneous |