drugset / Trial / NCT02421185

Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 (Erdafitinib) in Participants With Advanced Hepatocellular Carcinoma

NCT02421185

Phase 1/2 Completed 53 enrolled Janssen Research & Development, LLC
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to determine recommended Phase 2 dose \[RP2D\]) and the objective response rate of JNJ-42756493 (erdafitinib) in advanced hepatocellular carcinoma (HCC) participants with fibroblast growth factor (FGF) 19 amplification.

Timeline

Start
2015-05-25
Primary completion
2019-05-13
Completion
2019-05-16

Drugs

EvaluationDrugModalityDoseRoute
Subject Erdafitinib Small molecule 8 mg Oral