drugset / Trial / NCT02432235
Study of ADCT-301 in Patients With Relapsed or Refractory Hodgkin and Non-Hodgkin Lymphoma
Non-randomizedSequentialOpen-labelTreatment
Summary
This study evaluates camidanlumab tesirine in participants with relapsed/refractory Non-Hodgkin or Hodgkin lymphoma.
Timeline
- Start
- 2015-10-05
- Primary completion
- 2019-10-24
- Completion
- 2019-10-24
Publications
- Toukam M, Wuerthner J, Havenith K, Hamadani M, Caimi PF, Kopotsha T, Cruz HG, Boni JP. Population pharmacokinetics analysis of camidanlumab tesirine in patients with relapsed or refractory Hodgkin lymphoma and non-Hodgkin lymphoma. Cancer Chemother Pharmacol. 2023 Jan;91(1):13-24. doi: 10.1007/s00280-022-04486-4. Epub 2022 Nov 4.
- Toukam M, Boni JP, Hamadani M, Caimi PF, Cruz HG, Wuerthner J. Exposure-response analysis of Camidanlumab tesirine in patients with relapsed or refractory classical Hodgkin lymphoma and non-Hodgkin lymphoma. Cancer Chemother Pharmacol. 2023 Jan;91(1):1-12. doi: 10.1007/s00280-022-04487-3. Epub 2022 Nov 4.
- Hamadani M, Collins GP, Caimi PF, Samaniego F, Spira A, Davies A, Radford J, Menne T, Karnad A, Zain JM, Fields P, Havenith K, Cruz HG, He S, Boni J, Feingold J, Wuerthner J, Horwitz S. Camidanlumab tesirine in patients with relapsed or refractory lymphoma: a phase 1, open-label, multicentre, dose-escalation, dose-expansion study. Lancet Haematol. 2021 Jun;8(6):e433-e445. doi: 10.1016/S2352-3026(21)00103-4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ADCT-301 | Monoclonal antibody | 3 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 5 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 8 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 13 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 20 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 30 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 45 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 60 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 80 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 100 ug/kg | Intravenous |
| Subject | ADCT-301 | Monoclonal antibody | 150 ug/kg | Intravenous |