drugset / Trial / NCT02432651
Xanthohumol and Prevention of DNA Damage
RandomizedCrossoverQuadruple-blindPrevention
Summary
The purpose of this research study is to learn if and in what amount a compound from hops, called xanthohumol (ZAN-tho-HUE-mol), prevents damage to DNA and oxidative stress. The human body is constantly exposed to oxidative stress from environmental compounds (e.g. air pollution) which may cause damage to DNA. The human body can repair some DNA damage, but too much DNA damage is harmful and may lead to cancer. Research done at OSU and around the world has shown that xanthohumol can stop or slow processes that lead to cancer.
Timeline
- Start
- 2015-03
- Primary completion
- 2016-06
- Completion
- 2017-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Xanthohumol | Small molecule | 6 mg | Oral |
| Subject | Xanthohumol | Small molecule | 12 mg | Oral |
| Subject | Xanthohumol | Small molecule | 24 mg | Oral |