drugset / Trial / NCT02432651

Xanthohumol and Prevention of DNA Damage

NCT02432651 ↗

Phase 1 Completed 64 enrolled Oregon State University
RandomizedCrossoverQuadruple-blindPrevention

Summary

The purpose of this research study is to learn if and in what amount a compound from hops, called xanthohumol (ZAN-tho-HUE-mol), prevents damage to DNA and oxidative stress. The human body is constantly exposed to oxidative stress from environmental compounds (e.g. air pollution) which may cause damage to DNA. The human body can repair some DNA damage, but too much DNA damage is harmful and may lead to cancer. Research done at OSU and around the world has shown that xanthohumol can stop or slow processes that lead to cancer.

Timeline

Start
2015-03
Primary completion
2016-06
Completion
2017-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Xanthohumol Small molecule 6 mg Oral
Subject Xanthohumol Small molecule 12 mg Oral
Subject Xanthohumol Small molecule 24 mg Oral