Testosterone Therapy in Hypogonadal Men Treated With Opioids

Summary

The purpose of this study is to evaluate the efficacy of testosterone replacement therapy in men with low testosterone due to opioid treatment on body composition, the haemostatic system, glucose metabolism, muscle function, pain sensitivity, pain modulation, lipids, sexual function and quality of life. Male patients on opioids for non-malignant diseases aged 18-59 years diagnosed with hypogonadotrophic hypogonadism, referred from day hospitals and outpatient populations. 40 patients are randomized to either testosterone undecanoate i.m. or placebo i.m., i.e. 20 patients per arm A double blinded randomized placebo controlled trial

Timeline

Start

2015-05-01

Primary completion

2019-09-01

Completion

2019-09-01

Publications

• Olesen TB, Glintborg D, Johnk F, Olsen MH, Andersen MS. Blood pressure responses to testosterone therapy are amplified by hematocrit levels in opioid-induced androgen deficiency: a double-blind, randomized, placebo-controlled trial. J Hypertens. 2024 May 1;42(5):893-901. doi: 10.1097/HJH.0000000000003638. Epub 2023 Dec 13.

Drugs

Indications