Antibiotics in Free Flaps Reconstructions

Phase 4 Completed 350 enrolled Technical University of Munich

RandomizedParallel-groupSingle-blindPrevention

Summary

The purpose of this study is to monitor and compare peri-operative problems and outcomes of reconstructive surgery with microvascular free flaps in the head and neck region between groups of patients treated with perioperative antibiotics and a group of patients without antibiotics.

Timeline

Start: 2007-07
Primary completion: 2012-06
Completion: 2014-12

Publications

Mucke T, Rohleder NH, Rau A, Ritschl LM, Kesting M, Wolff KD, Mitchell DA, Loeffelbein DJ. The value of perioperative antibiotics on the success of oral free flap reconstructions. Microsurgery. 2015 Oct;35(7):507-11. doi: 10.1002/micr.22470. Epub 2015 Aug 7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Amoxicillin	Other / unclassified	—	Intravenous
Comparator	Benzylpenicillin	Unknown	—	Intravenous
Comparator	Cefuroxime	Small molecule	—	Intravenous
Comparator	Sulbactam	Small molecule	—	Intravenous

Indications

No indication recorded.