Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip

Summary

The primary objective of this study is to evaluate the effectiveness of REGN475 compared to placebo in participants with pain due to osteoarthritis (OA) of the knee or hip and a history of inadequate joint pain relief or intolerance to current analgesic therapy.

Timeline

Start

2015-05

Primary completion

2016-03

Completion

2016-11

Publications

• Eng S, Fetell M, Gao H, Mei J, Trejos J, Cortes-Burgos L, Ho T, Manvelian G, Patel Y, Trinh N, Turner KC, Hassan HE, DiMartino S, Krueger P, Geba GP, Braunstein N, Macdonald LE, Soltys R, Croll SD, Dakin P. The Effects of Fasinumab on Peripheral Nerve Function and Ganglion Anatomy: Results From a Randomized, Double-Blind, Placebo-Controlled Study in Patients With Pain Due to Osteoarthritis of the Knee or Hip, and a Series of Nonclinical Studies. Curr Ther Res Clin Exp. 2025 Oct 24;103:100813. doi: 10.1016/j.curtheres.2025.100813. eCollection 2025.
• Dakin P, DiMartino SJ, Gao H, Maloney J, Kivitz AJ, Schnitzer TJ, Stahl N, Yancopoulos GD, Geba GP. The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Arthritis Rheumatol. 2019 Nov;71(11):1824-1834. doi: 10.1002/art.41012. Epub 2019 Sep 20.

Drugs

Indications