drugset / Trial / NCT02451072
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers
NaSingle-groupDouble-blindBasic science
Summary
Aim of the present study is to investigate the neuronal correlates of self and of personal meaning as well as the role of the serotonin (5-HT) 2A receptor system in these processes using functional magnetic resonance imaging (fMRI) and psychometric and cognitive measures.
Timeline
- Start
- 2015-03
- Primary completion
- 2016-01
- Completion
- 2016-01
Publications
- Burt JB, Preller KH, Demirtas M, Ji JL, Krystal JH, Vollenweider FX, Anticevic A, Murray JD. Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD. Elife. 2021 Jul 27;10:e69320. doi: 10.7554/eLife.69320.
- Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stampfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. Elife. 2018 Oct 25;7:e35082. doi: 10.7554/eLife.35082.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketanserin | Small molecule | 40 mg | Oral |
| Subject | LSD | Unknown | 100 ug | Oral |
Indications
No indication recorded.