drugset
drugset / Trial / NCT02457845

HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors

NCT02457845 ↗

Phase 1 Completed 13 enrolled Gregory K. Friedman, MD Battle for a Cure Foundation · collabCannonball Kids' Cancer Foundation · collabEli Jackson Foundation · collabEli's Block Party Childhood Cancer Foundation · collabFood and Drug Administration (FDA) · collabHyundai Hope On Wheels · collabJaxon's F.R.O.G. Foundation · collabKaul Pediatric Research Institute · collabKelsie's Crew · collabMemorial Sloan Kettering Cancer Center · collabNational Center for Advancing Translational Sciences (NCATS) · collabRally Foundation for Childhood Cancer Research · collabSandcastle Kids · collabSt. Baldrick's Foundation · collabThe Andrew McDonough B+ Foundation · collabUnited States Department of Defense · collabUniversity of Alabama at Birmingham · collab
NaSingle-groupOpen-labelTreatment

Summary

This study is a clinical trial to determine the safety of injecting G207 (a new experimental virus therapy) into a recurrent or progressive brain tumor. The safety of combining G207 with a single low dose of radiation, designed to enhance virus replication and tumor cell killing, will also be tested.

Timeline

Start
2016-05
Primary completion
2020-06
Completion
2024-01

Publications

Drugs

EvaluationDrugModalityDoseRoute
Subject G207 Other / unclassified 1e+07 unknown Other
Subject G207 Other / unclassified 1e+08 unknown Other

Indications

anaplastic astrocytoma cerebral primitive neuroectodermal tumor glioblastoma primitive neuroectodermal tumor