drugset / Trial / NCT02461056
Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Intravenous form of ibuprofen is recently approved by FDA and reports are rare on the co-administration with opioids. The investigators searched whether intravenous ibuprofen-hydromorphone combination is synergistic, additive, or infra-additive on postoperative pain using combination index (CI), dose reduction index (DRI) and isobologram.
Timeline
- Start
- 2014-06
- Primary completion
- 2014-07
- Completion
- 2014-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Hydromorphone | Other / unclassified | 0.125 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 0.25 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 0.5 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 0.75 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 1 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 1.5 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 2 mg | Intravenous |
| Comparator | Ibuprofen | Small molecule | 25 mg | Intravenous |
| Comparator | Ibuprofen | Small molecule | 50 mg | Intravenous |
| Comparator | Ibuprofen | Small molecule | 100 mg | Intravenous |
| Comparator | Ibuprofen | Small molecule | 200 mg | Intravenous |
| Comparator | Ibuprofen | Small molecule | 400 mg | Intravenous |
| Comparator | Ibuprofen | Small molecule | 800 mg | Intravenous |