drugset / Trial / NCT02468063
To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock
RandomizedParallel-groupOpen-labelTreatment
Summary
The consecutive patients admitted to Intensive care unit of Hepatology department of ILBS and full filling all the eligibility criteria will be enrolled in 1:1 ration by the process of randomization.- The study is an open level study. The investigators will strictly follow the randomization table to give therapy as per the intervention arm. * Intervention:-the therapeutic intervention is vasopressor i.e. noradrenaline alone and terlipressin along with noradrenaline to maintain the MAP \>65mm Hg. * Intervention arm * Arm (A) - Noradrenaline * Arm (B) - Noradrenaline + low dose terlipressin
Timeline
- Start
- 2015-05-01
- Primary completion
- 2017-05-31
- Completion
- 2017-05-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Noradrenaline | Unknown | 3.75 ug | — |
| Comparator | Noradrenaline | Unknown | 7.5 ug | — |
| Comparator | Noradrenaline | Unknown | 30 ug | — |
| Comparator | Noradrenaline | Unknown | 60 ug | — |
| Subject | Terlipressin | Peptide | 2 mg | — |