drugset / Trial / NCT02472847
Cannabinoid Control of Fear Extinction Neural Circuits in Humans
Phase 4
Completed
85 enrolled
University of Illinois at Chicago
National Institute of Mental Health (NIMH) · collabNational Institutes of Health (NIH) · collab
RandomizedParallel-groupDouble-blindBasic science
Summary
The goal of the current proposal is to investigate the effects of a cannabinoid drug on the memory of extinguished fear in humans and the brain circuitry important for the recall of extinction learning. The investigators findings will translate previous discoveries from animal studies to humans and increase their understanding of the neurobiological mechanisms supporting retention of extinction memory. This proof-of-concept study is a critical translational first step towards the development of cannabinoid modulators as an adjunctive strategy to exposure-based therapies to augment extinction learning and prevent the return of fear memories in patients with post-traumatic stress and other anxiety disorders.
Timeline
- Start
- 2012-05
- Primary completion
- 2014-07
- Completion
- 2014-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dronabinol | Other / unclassified | 7.5 mg | Oral |
Indications
No indication recorded.