A Bronchoscopy Study to Assess the Effects of Inhaled Corticosteroids on Adult Healthy Volunteers

Phase 4 Active not recruiting 30 enrolled University Hospitals, Leicester Genentech, Inc. · collab

RandomizedParallel-groupOpen-labelBasic science

Summary

This is a randomized, single-blind, controlled, single centre bronchoscopy study designed to assess the effects of fluticasone propionate on airway gene expression and cellularity in healthy adult controls without asthma.

Timeline

Start: 2016-01-20
Primary completion: 2026-10-31
Completion: 2026-10-31

Publications

Marchi E, Hinks TSC, Richardson M, Khalfaoui L, Symon FA, Rajasekar P, Clifford R, Hargadon B, Austin CD, MacIsaac JL, Kobor MS, Siddiqui S, Mar JS, Arron JR, Choy DF, Bradding P. The effects of inhaled corticosteroids on healthy airways. Allergy. 2024 Jul;79(7):1831-1843. doi: 10.1111/all.16146. Epub 2024 Apr 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Fluticasone propionate	Other / unclassified	500 ug	Inhaled

Indications

No indication recorded.