Neuroimaging Study of Risk Factors for Adolescent Bipolar Disorder

Summary

The main purpose of this study is to see the affects of the study medication called mixed amphetamine salts-extended release (MAS-XR) on brain function by taking brain pictures. The researchers also want to see if MAS-XR makes your child more or less likely to develop problems like acting out (i.e. periods of irritability, agitation, aggression). MAS-XR is approved by the United States Food and Drug Administration (FDA) to treat attention deficit hyperactivity disorder (ADHD) in adults, children and adolescents.

Timeline

Start

2015-11

Primary completion

2022-08

Completion

2022-12

Publications

• Qin K, Pan N, Lei D, Zhu Z, Tallman MJ, Patino LR, Gong Q, Sweeney JA, DelBello MP, McNamara RK. Different Changes in Brain Functional Networks Following 12-Week Psychostimulant Treatment in Attention-Deficit/Hyperactivity Disorder Youth With and Without Familial Risk for Bipolar I Disorder. J Am Acad Child Adolesc Psychiatry. 2025 Jul 23:S0890-8567(25)00751-8. doi: 10.1016/j.jaac.2025.07.421. Online ahead of print.

Drugs

Indications